Francesco Saverio Bersani, Angela Iannitelli, Francesca Pacitti, Giuseppe Bersani

SUMMARY. Sleep problems and circadian rhythms disturbances are common in many psychiatric disorders, with the most-often-reported sleep problem in most cases being insomnia. In this paper, the main findings about sleep disturbances (features and therapy) and other biorhythm disturbances (biological timekeepers, CLOCK genes, GSK3, melatonin, hypothalamo-pituitary-adrenal axis, body temperature) are reviewed in relation to schizophrenia, mood and anxiety disorders.